Tag: congress

‘Danger sign’: State, local government job losses grow as Congress stalls on relief

The new data undercut a Republican argument that state and local governments have gotten enough help from Washington, with some citing an uptick in revenue for many states this summer that outpaced initial projections. But the job losses suggest that economic relief that Congress approved in the CARES Act in late March gave a temporary boost to local economies that’s now drying up.

Not all Republicans have rejected more state aid outright. In an interview, Sen. Bob Menendez (D-N.J.) cited three Republican cosponsors — Sen. Bill Cassidy of Louisiana, Cindy Hyde-Smith of Mississippi and Susan Collins of Maine — for his bill to provide $500 billion in flexible grants to help state and local governments.

“One of the lessons we should take from the Great Recession was that massive layoffs and tax increases at the state and local level acted as an anchor and weighed down our economic recovery for years to come,” Menendez said. “We shouldn’t repeat that.”

He pointed to a Moody’s Analytics report this month that predicted the fiscal shock for state and local governments could run as high as $450 billion, or 2.2 percent of the economy. However, that figure assumes an additional stimulus, projected at approximately $1.5 trillion, from the federal government arriving sometime in the fall.

Rep. Tom Cole (R-Okla.), a member of the House Republican leadership and a senior appropriator, told POLITICO that if lawmakers fail to reach agreement soon, the economy could “lose the momentum that we created over the summer.”

“There’s a lot of things that were actually generating revenue for states that are ending,” Cole said, referring to unemployment benefits, stimulus checks and coronavirus support funds.

Even though many of his fellow Republicans think no more aid is needed, the “political reality is if you want a package, there’s going to have to be state and local and tribal aid in it, period,” Cole said.

Meanwhile, local budget officials have kept up a steady call for more aid. They also warn that federal funds already provided can’t be used the same way by all states.

Colorado Treasurer Dave Young said that even though the state managed to fill shortfalls earlier this year using reserves, the drawdown led to automatic spending cuts because a certain level of reserve funds is required by statute.

Young said the state also has difficulty using the Municipal Liquidity Facility, which the Federal Reserve set up in April as a backstop emergency lending source for states in financial distress. With so few states using the facility, Sen. Pat Toomey (R-Pa.) has suggested that officials wind it down.

But Young said the facility, which lends short-term debt at above-market rates to be paid off over a maximum of three years, isn’t a viable option for Colorado, because state law requires that any borrowing must be paid off in the same fiscal year it is made.

“When they say, ‘Well, you’re not utilizing it!’ Well, there’s a number of reasons we’re not utilizing it. None of them have

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Fulcrum Therapeutics Announces Multiple Presentations During the Virtual 25th International Congress of the World Muscle Society

CAMBRIDGE, Mass., Oct. 01, 2020 (GLOBE NEWSWIRE) — Fulcrum Therapeutics, Inc. (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today announced it will present multiple posters on the company’s ongoing studies in patients with facioscapulohumeral muscular dystrophy (FSHD) during the 25th International Congress of the World Muscle Society.

“FSHD is a serious and debilitating disease for which there are currently no approved therapies,” said Diego Cadavid, MD, Fulcrum’s senior vice president, clinical development. “We are pleased to share these data at this important scientific meeting as we continue to pursue losmapimod as a potential treatment for FSHD by addressing the root cause of the disease. We greatly appreciate the patients who have participated in our trials and the support we have received from key opinion leaders and investigators.”

During the Virtual Poster Session today, October 1, 2020 from 12:30pm – 2:30pm ET, Fulcrum will present four posters on its integrated approach to the evaluation of FSHD patients, highlighting the progress made in the development of imaging and molecular biomarkers in FSHD and the design of clinical trials to evaluate potential benefits of losmapimod in FSHD patients:

  • Development and Evaluation of a Whole-body MRI Protocol and Analysis Algorithms to Measure Changes in Skeletal Muscle in FSHD

  • A Biomarker of Aberrant DUX4 Activity to Evaluate Losmapimod Treatment Effect in FSHD Phase 2 Trials

  • Open-Label Pilot Study of Losmapimod in FSHD1 (NCT04004000)

  • A Phase 2, Randomized, Placebo-Controlled, 48-Week Study of the Efficacy and Safety of Losmapimod in Treating Subjects with FSHD: ReDUX4 (NCT04003974) Interim Analysis

The poster sessions will be available to registered conference attendees. The posters will also be made available in the “Publications” section of fulcrumtx.com.

About FSHD
FSHD is characterized by progressive skeletal muscle loss that initially causes weakness in muscles in the face, shoulders, arms and trunk, and progresses to weakness throughout the lower body. Skeletal muscle weakness results in significant physical limitations, including an inability to smile and difficulty using arms for activities, with many patients ultimately becoming dependent upon the use of a wheelchair for daily mobility.

FSHD is caused by mis-expression of DUX4 in skeletal muscle, resulting in the presence of DUX4 proteins that are toxic to muscle tissue. Normally, DUX4-driven gene expression is limited to early embryonic development, after which time the DUX4 gene is silenced. In people with FSHD, the DUX4 gene is turned “on” as a result of a genetic mutation. The result is death of muscle and its replacement by fat, leading to skeletal muscle weakness and progressive disability. There are no approved therapies for FSHD, one of the most common forms of muscular dystrophy, with an estimated patient population of 16,000 to 38,000 in the United States alone.

About Losmapimod
Losmapimod is a selective p38α/β mitogen activated protein kinase (MAPK) inhibitor that was exclusively in-licensed from GSK by Fulcrum Therapeutics following Fulcrum’s discovery of the role of p38α/β inhibitors in the reduction of DUX4 expression and an extensive

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Scholar Rock Presents Data for SRK-015 at the World Muscle Society 2020 Virtual Congress

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Sep 30, 2020–

Scholar Rock (NASDAQ: SRRK), a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, today announced two poster presentations as part of the World Muscle Society (WMS) 2020 Virtual Congress. The SRK-015 clinical development poster will showcase previously presented data from the Phase 1 healthy volunteer trial, as well as baseline characteristics and demographics from the TOPAZ Phase 2 proof-of-concept trial evaluating SRK-015 for the treatment of patients with Type 2 and Type 3 Spinal Muscular Atrophy (SMA). The second poster shares data on the pharmacologic effects of SRK-015 in patients with SMA, healthy volunteers, and across animal species.

Details for the two virtual posters at the WMS meeting are as follows:

  • Title: Clinical Development of SRK-015, a Fully Human Anti-proMyostatin Monoclonal Antibody, for the Treatment of Later-Onset Spinal Muscular Atrophy
  • Title: Myostatin Dynamics in Health and Disease: Pharmacologic Effects of SRK-015, a Highly Selective Monoclonal Antibody Inhibitor of Myostatin Activation
  • Virtual poster presentations on October 1, 2020 at 17:30-19:30 BST.

The SRK-015 TOPAZ Phase 2 clinical trial is fully enrolled, and a 6-month interim efficacy and safety analysis is planned for the fourth quarter of 2020 with top-line data for the 12-month treatment period expected in the first half of 2021. As of September 25, 2020, 22 patients across the three cohorts have completed the 12-month treatment period, and all 22 have opted into the 12-month extension period.

About SRK-015

SRK-015 is a selective inhibitor of the activation of myostatin and is an investigational product candidate for the treatment of patients with spinal muscular atrophy (SMA). Myostatin, a member of the TGFβ superfamily of growth factors, is expressed primarily by skeletal muscle cells, and the absence of its gene is associated with an increase in muscle mass and strength in multiple animal species (1). Scholar Rock believes the inhibition of the activation of myostatin with SRK-015 may promote a clinically meaningful increase in muscle strength (2). A Phase 2 clinical trial in patients with Type 2 and Type 3 SMA is ongoing (NCT03921528). The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) and Rare Pediatric Disease (RPD) designation, and the European Commission (EC) has granted Orphan Medicinal Product Designation, to SRK-015 for the treatment of SMA. The effectiveness and safety of SRK-015 have not been established and SRK-015 has not been approved for any use by the FDA or any other regulatory agency.

(1) Han, H.Q., Zhou, Xiaolan, Goldberg, A. Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential. International Journal of Biochemistry & Cell Biology, 2013, 45(10):2119-2348

(2) Long, K., O’Shea, K., Khairallah, R., et al. Specific Inhibition of Myostatin Activation is Beneficial in Mouse Models of SMA Therapy. 2018. Human Molecular Genetics, ddy382

About Scholar Rock

Scholar Rock is a clinical-stage biopharmaceutical company focused on the discovery and development of innovative medicines for the treatment of serious diseases in which signaling by protein growth factors plays a

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Can Members Of Our U.S. Congress Retire With Full Pay After Just One Time period? The

Political science has a relationship in the study of regulation. Agree, as said in this hub, that in comparison with most individuals, our congress members have got it pretty good even if it is not as posh as rumored. I also discover it ironic that the Tea Celebration, which claims to revere the Structure, is so vital of the concept of a robust national government.

The spirit of this essay is proven in the Preamble of the Constitution, We the folks of the United States, to be able to form a extra excellent union” may be linked to Hamilton statement the fate of an empire”, as a result of it will take the people of the nation to come back together and form a union to create a stronger government (Association, 2013).

A) In a federal state there are two units of governments, one is called federal or central government, the other is provincial or Unit union of those two units of governments makes what is named governments is independent of the other in its personal central and unit governments are constitutionaly equal in status and place:non s superior to different.

Due to this fact, to cut back the nationwide debt, the federal government should both reduce the amount of cash it spends (by means of slicing applications or reducing costs) or increase the sum of money it takes in (through elevated taxes or other income streams).

If we do nothing and never let our government know that we are good informed Americans, who won’t let our Nation be offered out for Money, Energy and Greed. The government banned certain guns in Australia and a gun mafia was not created. The United States has federal, state and local government.…

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Can Members Of Our U.S. Congress Retire With Full Pay After Just One Term? The

Political science has a relationship in the examine of legislation. Whatever, you do learn and analysis Agenda 21 – that is our nation we’ll give to the enemy and our American way of life, if we do not stand-up towards it. The Supreme Court may also resolve whether federal, state, and native governments are following the law.

The Nazis focus of on propaganda that made the average German citizen think if the Nazi celebration got here to energy there can be one thing for everyone (aside from these peoples the Nazis demonized like Jews and Gypsies). By eliminating the impediment of resistance from the folks, the company agenda to purchase the government of the United States can proceed with out interruption.

The definition of a Republic is: a constitutionally limited government of the consultant type, created by a written Constitution-adopted by the individuals and changeable (from its authentic which means) by them only by its modification-with its powers divided between three separate Branches: Government, Legislative and Judicial.

That is additionally a part of the republic definition, the Federal government wasn’t created to control the people or states, the republic is the coalition of states that govern themselves, this was bastardized when people have been allowed to vote for state senators instead being appointed.

But since so many individuals wish to imagine it, it is now quoted by the NRA and different anti-gun control advocates. That is in regards to the structure, SCOTUS and political parties concept of government, not faith. Makes folks aware of the laws of the land: The structure helps citizens grow to be aware of the legal guidelines of their land and the consequences of going contrary to the laws.…

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British Parliament Vs. United States Congress

Political science has a relationship in the study of law. Many of the weapons used by criminals are already illegal. A prohibition in opposition to retroactive (ex submit facto) legal legal guidelines guarantees people know the legal guidelines earlier than the government prosecutes them for a given action. As Hitler and his Nazi party grew in energy, the “Regulation on Firearms and Ammunition” was enacted.

This must be read Au fait, by every American that cared how this country is run. Watkins as I promised you, I read your hooked up hub in one in every of my HP’s articles this is a very interesting narrative about the Progressive Motion, which I discover one of the most fascinating periods of American fashionable historical past.

It was far simpler for him to use his speeches, Nazi help, the legal guidelines already in place, and the psychological & financial mindset of the German folks to grow to be Chancellor of Germany and from there grow to be the dictator that initiated and orcestrated the Second World War.

James Madison, Thomas Jefferson and others, held that the federal government was not the only or ultimate decide of its own authority, holding that this might “make it, and never the Structure, the choose of its powers. Let me carry up one other, related, subject – that of legal guidelines making double murder costs against those who kill a pregnant lady.

B) In a federation governmental powers are basically distributed by the structure between the Central government on the one hand and the unit government on the small print of division vary in different the principle folllowed in the division is that all matters which are primarily of common interest and require uniformity of regulation throughout the nation reminiscent of overseas affairs,defence,foreign money and coinage are positioned below the central government, and the resr is left to the Unit governments.…

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People Had been Offered Out For Cash, Power And Greed By Congress

Political science has a relationship within the research of law. The United States is still arguing over what the stability of powers needs to be between the states and the national government. ‘Bowser’) for his aggressive method – is the eldest serving member, whichever occasion he belongs to. Sessions within the Commons resemble break time in a public college frequent room (or Chimps’ Tea Occasion at the zoo).

Certainly, it is even sadder that these Congress people who are sitting fairly are the very ones who’re slicing social packages like meals stamps as a result of the imagine people have an excessive amount of. Anarchists need no legal guidelines or government to impede their society, though this has not been formally tried on a large scale.

After World Struggle I, the German government, by order of the Treaty of Versailles, stripped all citizens of their right to personal guns. The way that the people of France eradicated their Oligarchical government was to terminate the lives of the highly effective elites.

Written constitution: This is where all of the laws governing a rustic are codified into a single doc or guide. (3) Political law has two areas particularly: the constitutional legislation; and administrative regulation. Versatile constitution: This is a kind of constitution whose guidelines or laws are very simple to amend or change.

Legal guidelines are like rules for a whole country. Among other influences on the framers option to divide the government into three separate branches, was the Magna Carta and Mayflower Compact (Constitution of the United States of America, 2009). Hitler enacted a legislation that ensured Jews could not have guns.…

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