Tag: results

Bayer to Present Results From Phase III FIDELIO-DKD Study with Finerenone in Patients with Chronic Kidney Disease and Type 2 Diabetes during Late-Breaker Session at the American Society of Nephrology’s Kidney Week 2020

WHIPPANY, N.J.–(BUSINESS WIRE)–Bayer will present detailed results from the Phase III FIDELIO-DKD study assessing the use of the investigational drug finerenone on kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) during scientific sessions of the upcoming American Society of Nephrology’s (ASN) Kidney Week, October 22-25, 2020. Additional data evaluating use of finerenone will also be presented.

The FIDELIO-DKD study, which evaluated the efficacy and safety of finerenone versus placebo when added to standard of care in patients with CKD and T2D, is the first large contemporary positive outcomes study in patients with CKD and T2D with a primary composite endpoint exclusively consisting of kidney-specific outcomes. Bayer announced earlier this year that FIDELIO-DKD met its composite primary renal endpoint and its composite key secondary cardiovascular endpoint.

Full data from the FIDELIO-DKD study will be presented as part of the live-streamed, late-breaker oral abstract session High-Impact Clinical Trials:

  • “Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes” – October 23, 2020, 10:30 –10:45 am (EDT) (Abstract FR-OR51)

Additional scientific presentations include:

About the Finerenone Phase III Clinical Program

Finerenone (BAY 94-8862) is an investigational, non-steroidal, selective mineralocorticoid receptor antagonist.1 The Phase III clinical program with finerenone in CKD and T2D is the largest Phase III clinical trial program to date in CKD and T2D having 13,000 randomized patients across a broad range of disease severity including those with early kidney damage and more advanced stages of kidney disease. The clinical program comprises two studies (FIDELIO-DKD and FIGARO-DKD), evaluating the effect of finerenone versus placebo in addition to the standard of care in both renal and cardiovascular outcomes.

FIDELIO-DKD (FInerenone in reducing kiDnEy faiLure and dIsease prOgression in Diabetic Kidney Disease) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven Phase III study that investigated the efficacy and safety of finerenone in comparison to placebo in addition to standard of care on the reduction of kidney failure and kidney disease progression in approximately 5,700 patients with CKD and T2D from more than 1,000 sites across 48 countries worldwide.

FIGARO-DKD (FInerenone in reducinG cArdiovascular moRtality and mOrbidity in Diabetic Kidney Disease) is still ongoing and is investigating the efficacy and safety of finerenone versus placebo in addition to standard of care on the reduction of cardiovascular morbidity and mortality in approximately 7,400 patients with CKD and T2D across 47 countries including sites in Europe, Japan, China and the U.S.

Bayer also recently announced the initiation of the FINEARTS-HF study, a multicenter, randomized, double-blind, placebo-controlled Phase III study which will investigate finerenone compared to placebo in more than 5,500 symptomatic heart failure patients (New York Heart Association class II-IV) with a left ventricular ejection fraction of ≥40%. The primary objective of the study is to demonstrate superiority of finerenone over placebo in

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New Michigan law lets ballot processing start early, but don’t expect results until Friday of election week

Michigan officials expect record-breaking turnout for the Nov. 3 election and Gov. Gretchen Whitmer has signed a few last-minute bills into law to speed the process and ensure every ballot is counted.

On Tuesday, Whitmer signed Senate Bill 757, passed by the House and Senate in September, to allow clerks in cities and townships with at least 25,000 people to start processing absentee ballots Nov. 2. The ballots can’t be tabulated until 7 a.m. on election day, however.

While the move is a “step in the right direction” per Secretary of State Jocelyn Benson, it’s not enough, she said. States like Kentucky, Ohio, North Carolina and Florida allow more time for processing – sometime weeks more, Benson said.

The change won’t significantly alter when the results will be ready, Benson said.

“We still expect that it will be the Friday of election week that we expect every ballot will be tabulated,” Benson said, noting it could be sooner.

This is the first presidential election in Michigan since voters passed a proposal allowing absentee voting without needing a specific reason.

The law also requires clerks to notify absentee voters if their ballot won’t be counted within 48 hours of receiving it – like for a missing signature, for example. This helps make sure every vote is counted, Whitmer said.

Senate Bill 117 was also supposed to be signed Tuesday, but Whitmer said Republican leadership didn’t send her the bill yet – despite it passing through both chambers of the Legislature.

The bill allows military members and their spouses to return ballots electronically through a secure portal if they can’t be returned in person. Benson’s husband served with the military in Afghanistan in 2004 and attempted to vote, she said, but couldn’t because a law like this wasn’t on the books.

“For some reason, the Republican leaders in the Legislature chose not to send me this bill yet,” Whitmer said. “I’m not sure what’s going on there, but this is crucial for our brave folks and their families who serve in the military. Elections are no time to play partisan games.”

More than 2.7 million ballots have been requested in Michigan so far, and 2.6 million of them have been issued to voters. Nearly 400,000 have been filled out and received back.

Here’s a look at which cities have the most requests for ballots, along with how many have been issued and how many have been submitted:

  1. Detroit: 124,400 (108,065 issued, 12,426 received)
  2. Grand Rapids: 51,711 (51,124 issued, 11,633 received)
  3. Ann Arbor: 47,645 (43,827 issued, 3,108 received)
  4. Livonia: 35,722 (35,457 issued, 8,071 received)
  5. Sterling Heights: 34,815 (33,670 issued, 3,836 received)

More than 450 communities have had at least 1,000 people request an absentee ballot so far.

Michigan residents can check their voter registration, register to vote and track the status of their absentee ballot at Michigan.gov/vote.

The state is also launching an advertising effort this week to put ads on social media, the internet, TV and the back of ATM receipts to

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Classifications Of Legislation, Destructive And Optimistic Results Of Law

In discussing women’s issues and history, you will need to analyze and discuss the influence and influence of patriarchal religion. Family life, for instance, is almost solely controlled by ladies. My research means that this male-centric thought is extremely flawed; that it might have been the women who gave energy to the boys. That is precisely what was males’ honor, nobility and chivalry was, their subordination to Us. Women and kids first (women first chidren subsequent) present how a lot We are valued.

The government of each country ought to perceive the importance of coaching and improvement and make effort to coach the feminine which then will give birth” to proper development; and therefore reduces feminine gender inequality. The recognition of human rights, typically expressed in a legally binding invoice of rights, is a response towards such tyrannies meant to limit the power of the government.

Youngsters from a younger age will be taught traits and values from household. Have you ever requested why so many individuals needed to sacrifice lives for the betterment of life.Maybe, they misplaced lives because the society simply failed to play its true role.

Training of the persons who keep regulation and order in the society is the obligatory part of it. There are such areas which ought to be trained before enforcement. People utilize #scams towards their household and friends typically without information or intention.

It’s painful that many families do not pay good consideration to their feminine children as a result of the households don’t see them as being very valuable to them when compared with the male. I do not think there will ever be any laws or guidelines banning male oriented products or promoting, it’s just that the goal market will probably be more and more Female.…

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Classifications Of Law, Destructive And Positive Results Of Law

A society is especially outlined as a group of people. It was a dynamic time for a lot of reasons, including politics, the life of MLK, the creation of children’s toys, and the rise of the hippies. In a government of equal numbers of women and men, there is nothing to cease males fiercely competing towards the women for power.

By reiterating the saying from Douglass’ guide in a contemporary voice midwives in Chennai have been typically paid $2.50 to smother a child girl born with a cleft deformity” Levitt and Dubner present how little value the lives of those dehumanized people carry.

Rosie the Riveter will be held accountable for this distinctive increase in working women during the Forties, nevertheless it was the continuous increase and life-style variations after this decade that showcased how deeply this character influenced females.

The Greek Civilization nevertheless, was more emphatic about the human kind, its poise, and wonder, reflecting mostly on the attires, physique languages, hairstyles, and cultures prevailing over totally different periods. This demonstrates that although the regulation has taken many years to be codified, it’s evolving to reflect society’s values by allowing this expertise to be accessed by all individuals in the neighborhood, whatever the sexuality.

Nevertheless, the disparity and injustice created by regulation is basically reduced as a result of prevalence of the moral values in the society which need not to be codified in the statute books. However, when family values are sturdy, it leads to the discount of particular person freedom and decline in the individual values.…

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Causes And Results

In 6th century Athens, three teams of inhabitants were created after the adjustments initiated by Solon. This will serve, partly, to reconnect many Africans who’re far removed from our ancient and conventional intergenerational cultural transmission processes. Properly, I am editorializing about things South African and why it’s so important to air these factors of view the Internet and Social Media.

Federalism is a system primarily based upon democratic guidelines and institutions in which the facility to govern is shared between national and state governments, If the Celebration believes that “sharing” must be weighted toward the central government then it will be designated with the symbol “F”; if the “sharing” is weighted towards the states, then the image is “f” and could be considered “states-rightists”.

I do not know for a reality, as an ordinary layman if propaganda and the manipulation of the US Media by the Terror group, ISIS, Al Qaeda, Bolo Haram and so forth is it not a part of the Cyberwar we are now somewhat accustomed to, as to the writing of this Hub.

When it come to ideas about the economy, what has really occurred is that the GOP, instantly after Obama’s inauguration, announced that Obama is going to be a ‘one-time president,’ that the y are going to verify he fails in the whole lot he does, and that they have been going to tarnish his governance and legacy.

Consequently, once they came into contact with Africa’s splendor, Europeans felt insufficient, ashamed, inferior, as a result of they’d constructed nothing similar in Europe, only weapons of struggle, and so they had been envious and began plotting to take Africa for themselves and enslave African people and that is precisely what they’ve finished.…

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Classifications Of Law, Adverse And Constructive Results Of Law

Fashion is likely one of the most important factors when it comes to social interplay and standing. In distinction to Becker’s perspective of deviance, functionalists imagine deviance occurs when a person’s behaviour departs from the shared values of a society. Douglass’ exhibits how the slaves had been dehumanized when he says, there were horses and men, cattle and ladies, pigs and youngsters, all holding the identical rank within the scale of being, and have been all subjected to the identical slender examination”.

For the subscribers to a naturalistic perspective of morality, born out of evolutionary concept, they are often no goal framework from which to face exterior social life and classify behaviour as objectively right or fallacious as these are cultural and social values dependent on contextual components.

Uncover real individuals are human and carry lots of baggage. I believe that supertype makes a degree price contemplating when he says (hypothesizes?) that in partiarchical societies in historical past, ladies accepted subordination to males in return for cover from men.

In keeping with Campaigner Uzma Noorami “Usually the husbands are attacking the women because of the ability structure that exists inside our society; a really patriarchal system the place girls are treated as commodities.” There has lately been a rise in acid assaults on males by ladies, nonetheless as they say, “what goes round comes round,” and I see this as these men getting a fair style of their very own drugs.

It is patrairchal rule that is holding again human progress, our world can never become a greater place while males continue to rule it. I cannot understand why after 5 thousand years of patriarchal historical past why individuals can’t see this. Actually the Family Man makes Peter Griffon look smarter and fewer like an a-gap then a lot of people I meet then most days.…

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